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Pruritus was reported in 4%, 2%, and 2% of patients (including adolescents) receiving topiramate 50 mg/day, 100 mg/day, and 200 mg/day, respectively, for migraines in placebo-controlled (2%) clinical trials

Validation of L2-Cmu was confirmed by Biacore analysis and in murine fibroblasts (NIH-3T3) in vitro