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Some research has shown that even in the absence of functional beta-3 receptors, acute AOD-9604 administration still increased energy expenditure and fat oxidation, suggesting the peptide may influence brown fat or thermogenic pathways through additional mechanisms

doi: 10.1007/S11154-014-9289-5 27 KalinderiKPapaliagkasVFidaniL

Overall adverse events in placebo-controlled trials were similar between groups but variable between studies, although each study was unique in terms of patient population and background therapy use

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