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Importantly, the IL1RAPCD3null control retained IL1RAP binding but lacks CD3 engagement, and failed to reduce tumor burden or extend survival, supporting that CD3 engagement is required for therapeutic activity (Fig
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They lose the ability to absorb B12 as they can for other nutrients
Redox Rep 17:2846 Jobbagy S, Vitturi DA, Salvatore SR, Turell L, Pires MF, Kansanen E (2019) Electrophiles modulate glutathione reductase activity via alkylation and upregulation of glutathione biosynthesis
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