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In both types of testing, however, there will be some form of relation between dose (exposure) and effect, as the capacity of a substance to produce effects, its potency, will be represented by the dose (exposure) required to produce sensitization (or toxicity)

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Recovery time: Noting how quickly soreness resolves after activity

If heavy bleeding continues, it needs medical attention

the 2.4 mg dose produced 16.9%, only 3.7% more despite more than doubling the dose and significantly increasing GI side effects (Wilding et al., NEJM 2021)