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Some people feel appetite suppression at 2.5mg, but the clinical trials showed that meaningful weight loss begins at 5mg and increases with each dose escalation up to 15mg

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When norepinephrine is released into the synapse between neurons, the amount of norepinephrine available there is controlled by the norepinephrine transporter, NET.[ref] In POTS, research points to an excess of norepinephrine signaling, and this could be due to decreased NET activity, essentially allowing too much norepinephrine to remain in the synapse

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