Often not repairable if located in the avascular (white) zone
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Vitamin B12 deficiency can manifest in the following clinical conditions: - hyperchromic macrocytic megaloblastic anaemia (pernicious anaemia, Biermer's anaemia, Addison's anaemia), - funicular spinal disease
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Even absent these logistical hurdles, pharmaceutical companies might not want to invest in clinical trials
FAK-paxillin signaling is a well-characterized pathway through which cells coordinate adhesion turnover, focal adhesion remodeling, and migration