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Except for ELIXA and EXSCEL [56, 59], all other major CVOTs point towards cardiovascular benefits of GLP-1RAs [53, 54, 61, 63, 66,67,68]

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Glutamate-treated rats had higher albumin levels in their brain compared to control rats [20] Other agents that may increase BBB permeability : Aspartate, taurine, ATP, endothelin-1, NO, MIP-2, TNF-a, MIP2, IL-h, bradykinin, 5HT, histamine, thrombin, UTP, UMP, quinolinic acid, platelet activating factor, and free radicals [2] How Do Researchers Detect a Leaky BBB

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