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It primarily exerts its activity through binding to the IGF-1 receptor (IGF-1R), initiating intracellular signaling pathways involved in cellular growth, proliferation, differentiation, and survival

We are looking at DNA, oxidative stress, and carnitine levels to better understand the mechanisms of chemotherapy-induced peripheral neuropathy to begin with, because there is not a whole lot known in terms of mechanism, she said

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Serious Side Effects: Though rare, serious side effects include an increased risk of seizures, elevated blood pressure, and suicidal thoughts

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