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In zebrafish, 90-day exposure to Polyactic Acid (PLA) and Aged Polyactic Acid (APLA) MPs (120 mg/L) suppressed 5-HT and DA, decreased acetylcholinesterase activity in the brain and gut and downregulated BDNF/TrkB signaling, coinciding with neuronal apoptosis

Diagnosis typically involves blood tests and endoscopy with biopsy, since early symptoms can be vague and antibody testing alone isnt always reliable

Neas LM, Dockery DW, Ware JH, Spengler JD, Speizer FE, & Ferris BG Jr (1991) Association of indoor nitrogen dioxide with respiratory symptoms and pulmonary function in children

As always, it's a good idea to consult with a dermatologist or skincare expert when choosing products for specific concerns