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doi: 10.1016/j.expneurol.2008.11.021

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Upon binding of a ligand to a death receptor, Fas-associated death domain protein (FADD) is recruited and the death-inducing signaling complex (DISC) (for FasL/FasR, TRAIL/TRAIL-R1 or TRAIL-R2) or complex II (in the case of TNF/TNF-R1) is formed

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