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One of the important oxidant responsive cis elements (transcription factor binding sites) regulating GCL genes is the AP-1 binding site also called the TRE element

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Maar, K., Hetenyi, R., Maar, S., Faskerti, G., Hanna, D., Lippai, B., Takatsy, A., & Bock-Marquette, I

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AndTP53 mutations, EGFR amplification, and replication stress-induced DNA methylation collectively downregulate RB1 expression [20, 21]

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