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Muscle and Fat (Insulin Sensitivity): GLP-1 RAs enhance glucose uptake in muscle and adipose tissue via the PI3K/Akt pathway, improving overall insulin sensitivity (Zheng et al., 2024)

Activation of nucleus tractus solitarius GLP1 neurons leads to an attenuation of metabolic rate and a reduction of food consumption in both fed and fasted states in mice (Table 1) (Cheng et al., 2020

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Their normal function is to regulate the microtubule assembly, which helps axonal transport, neuronal outgrowth, and polarity [26, 43, 53]

Since 1ml is typically 100 units on an insulin syringe, each unit would contain 10 mcg of IGF-1 LR3 (1000 mcg / 100 units)

While Western clinical trial data on the specific combination is limited, the individual evidence bases for each peptide are substantial, and their mechanisms are complementary rather than redundant