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When released after eating, GLP-1 signals the pancreas to produce insulin, reduces the release of glucagon, slows stomach emptying, and communicates with the brain to increase feelings of fullness

The glucagon-driven thermogenesis increases heat production, but the caloric deficit reduces the body insulation effect

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Remove the medication, and the drivers reassert themselves

A systematic review of event rates in clinical trials in diabetes mellitus: the importance of quantifying baseline cardiovascular disease history and proteinuria and implications for clinical trial design

The FDA threshold was set for that population