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Individuals with certain health conditions, such as Lebers disease (a rare inherited eye disease), should avoid B12 supplements as it can worsen the condition

18 As Thakkar and Billa, they point out potential concerns for smokers, but again this is based on an article from 1970

Exploration of compounds influencing body composition at a cellular level

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Heres what well cover in this blog post: Why blood B12 levels rise with supplementation The safety of high B12 levels in healthy individuals When elevated B12 may require further investigation The medical consensus on B12 supplementation and safety Why Do Blood Levels of B12 Rise with Supplementation

Because of this, lots of people have mild to moderate vitamin B12 deficiencies due to unbalanced diets or other factors