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*Correspondence: Bingnan Cui, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Because these are separate receptor populations using different second messenger systems, simultaneous activation produces additive-to-synergistic GH pulse amplification without receptor competition or off-target hormone effects

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