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The first two principal components explained 37.9% of the total variance (PC1 = 23%, PC2 = 14.9%) (Figure S2)

Mechanistically, TXNIP regulates the inactivation of mechanistic target of rapamycin kinase complex 1 (MTORC1), thereby promoting autophagy

All animals were housed at Animal Experiment Center of Wenzhou Medical University under the following conditions: 3 mice/ cage (30 20 15 cm, length width height), 12 h dark/light cycle, room temperature (24 1) C, ambient humidity (50 10) %, with free access to food and water

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