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For example, this promotes fibrogenesis in the liver worsening the course of underlying hepatic disorders, and a similar worsening effect is observed on the course of other chronic disorders apparently not directly linked to iron homeostasis such as metabolic and cardiovascular disorders (Pietrangelo, 2016)

Hemachand T, Gopalakrishnan B, Salunke DM et al (2002) Sperm plasma-membrane-associated glutathione S-transferases as gamete recognition molecules

Proceedings of the National Academy of Sciences of the United States of America, 87 (5), 17151719

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Liver tissue from older donors, when exposed to plasma from younger donors, began synthesizing proteins at rates typical of much younger tissue