is retatrutide or tirzepatide better vs (Research Comparison) Retatrutide Explained for Beginners: Moving

For detailed comparison of these medication options, see our Zepbound vs Wegovy guide

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Retatrutide is a once-weekly injection that mimics three hormones involved in appetite, blood sugar, and how the body uses energy: GLP-1: lowers appetite and blood sugar GIP: lowers appetite and blood sugar Glucagon: increases energy expenditure and the breakdown of stored fat, including fat in the liver The glucagon component is what separates retatrutide from semaglutide, which mimics one hormone (GLP-1), and tirzepatide, which mimics two (GLP-1 and GIP)

GLP-1 receptor agonists were initially developed to improve glycemic control in type 2 diabetes by enhancing insulin secretion and inhibiting glucagon release, with additional effects on appetite regulation and gastric emptying later recognized as clinically relevant (Meloni et al

It remarkably reduces HbA1c levels (a blood test that averages 3 months of blood sugar levels)

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