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Mechanical factors play important roles

Thus, we explored the MPO activity in lung tissue with the treatment of GHK-Cu under the exposure of CS and found that GHK-Cu administration reduced the increase in MPO enzymatic activities induced by CS exposure (Figure 3A)

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Another meta-analysis also showed that prolonged treatment with higher doses of NAC (1200 mg/day) prevents exacerbations of COPD, while lower doses (600 mg/day) may be effective only for patients with chronic bronchitis, without COPD and without airway obstruction [57]

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