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NNMT (nicotinamide N-methyltransferase) is the enzyme 5-Amino-1MQ inhibits, and tissue expression varies significantly across organs: adipose tissue shows 812 higher NNMT activity than skeletal muscle, which is why subcutaneous injection near adipose depots produces localised effects rodent models couldn't predict

Journal of Clinical Endocrinology and Metabolism, 105(8), e2710-e2716

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It showed excellent safety with no serious adverse events and no IGF-1 elevation

Once diluted, the product can be stored for more than a month if all storage conditions are met

Holmes says some patients report slightly less nausea with tirzepatide than with semaglutide but the reason for this isnt clear yet