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The reasons for these changes, apart from excess ROS leading to increased GSH depletion in cardiomyocytes, are disturbances in the anabolic process of GSH, causing a further decrease in intracellular GSH content

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When GHK complexes with copper, it silences copper's redox activity, preventing the generation of damaging hydroxyl radicals while still allowing copper to be delivered into cells for use as an enzymatic cofactor

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