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Materials and methods Animals Male C57BL/6 mice weighing 1820 g were kindly provided by the Experimental Animal Center of Chongqing Medical University (Chongqing, China)

The Lancet , 397 (10278), 971984

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A three-year randomized, double-blind, placebo-controlled trial in 818 older adults (aged 50-70 years) with elevated homocysteine levels but normal serum vitamin B 12 levels found that folic acid supplementation (800 g/day) lowered homocysteine levels and improved measures of memory performance (115)