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In the drug metabolism studies from Manchester, UK (Table 1) , heightened theophylline clearance was the predominant finding in patients with idiopathic or alcoholic disease (18), indicating induction of CYP1A (70) - as by C18:2 fatty acids (eg in corn, peanut or linseed oil), polycyclic aromatic hydrocarbons and halogenated hydrocarbons (94)