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HSP 90 inhibitor AUY 922 can reverse Fulvestrant induced feedback reaction in human breast cancer cells

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The timeline varies based on your starting dose and dose escalation schedule

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For example, inflammatory cytokines like tumor necrosis factor-s (TNF-) can inhibit autophagy, and autophagy inhibition can further exacerbate inflammation, creating a vicious cycle that exacerbates insulin sensitivity (51)