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However, alcohol disrupts sleep architecture (particularly REM sleep), impairs melatonin production, and increases cortisol, essentially working against everything pineal peptides are trying to achieve

Zhang Z, Tai Y, Liu Z, Pu Y, An L, Li X, et al

These considerations have potential to account for the important observation that the LASSS-pretreatment displayed greater preventive effect on nitration of Y198 compared to Y250 (Figure 2b)

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Jariwalla et al