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Eumelanosomes are responsible for producing brown to black pigment, while pheomelanosomes produce red to yellow pigment

But the studies included were small and only lasted about 3 to 4 months

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4-HNE in high concentrations is one of the most toxic and mutagenic metabolites of lipid peroxidation for the cell ( Another important signalling metabolite that is generated through the cyclooxygenase-mediated peroxidation of PUFAs is malondialdehyde (MDA)

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