Whereas, direct hippocampal delivery of miR-125b mimic improved learning, memory and inhibited Tau phosphorylation and expression of DUSP6, and PPP1CA in C57BL/6 mice (Banzhaf-Strathmann et al., 2014)
NAC may prevent ferroptosis by activating Nrf2, which regulates the expression of metallothioneins, ferritins and ferroportins, thereby preventing iron accumulation
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Several studies have shown that free-radical-mediated neuronal dysregulation plays a key role in the pathophysiology of psychiatric diseases by increased SOD activity levels, such as in schizophrenia 42
Defects occur in both the NADPH oxidase complex itself and the enzymes of the PPP that yield the required NADPH, particularly G6PDH The Pentose Phosphate Pathway The pentose phosphate pathway (PPP) (also called hexose monophosphate shunt, HMS) consists of series of interconnected reactions that serve as an alternate route for the metabolism of glucose
