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The therapeutic utility of native GLP-1 is limited by its rapid degradation [2], primarily mediated by dipeptidyl peptidase-4 (DPP-4) and secondarily by neutral endopeptidases (NEPs) and renal clearance [3, 4]

Cardiovascular outcomes with glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes: A meta-analysis