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Fue desarrollado para propsitos de investigacin mediante la modificacin de la molcula nativa de IGF-1 de dos maneras: Una sustitucin de arginina en la posicin 3 (la R3 en el nombre) reemplazando el cido glutmico por arginina en la tercera posicin de aminocido de la secuencia Adicin de una extensin N-terminal de 13 aminocidos (el componente Long) una modificacin estructural que reduce dramticamente la afinidad de unin del IGF-1 LR3 a las Protenas de Unin al IGF (IGFBPs) La segunda modificacin es la farmacolgicamente crtica

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