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How Do Experimental Studies Evaluate Off-Target Hormonal Effects

In the landmark SURMOUNT-1 trial, participants on the 15 mg dose achieved average weight loss of 22.5% of body weight over 72 weeks

10.1080/17460441.2025.2555275 256 TangZ.KangB.LiC.ChenT.ZhangZ

Perform a patch test before first use to check skin sensitivity

Mutations in Hjv ( Hfe2 ) gene are considerably less frequent but lead to juvenile hemochromatosis with a high degree of iron overload and overt cardiac phenotype (7, 9)