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Individuals carrying certain alleles may experience more pronounced appetite suppression, faster energy utilization, or altered satiety signalingincreasing fatigue risk during early treatment or aggressive dose escalation

Genetic variants in the GLP1R and GIPR pathways may also correlate with injection sensitivity and metabolic response to tirzepatide

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doi: 10.1038/361362a0 35 WojtusciszynAArmanetMMorelPBerneyTBoscoD

Study Looked at Data From Nearly 37,000 Pregnancies To get more insight into how GLP-1s may affect pregnancy outcomes, researchers performed a meta-analysis

In some head-to-head studies, orforglipron demonstrated greater blood sugar reductions and more weight loss than oral semaglutide