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The Intracellular ferrous iron can be oxidized and exported by the membrane protein ferroportin (FPN), which currently is the unique iron efflux pump discovered that can release iron from cells (Ganz, 2005)

It activates a biological process known as lipolysis, which refers to the breakdown of fats and other lipids

Staying hydrated and eating small, protein-rich meals in the hours following injection also reduces symptom severity

Tumor suppressor p53 can recruit ubiquitin-specific protease 7 to reduce the proportion of H2Bub1 in the regulatory region of the SLC7A11 gene, leading to impaired GSH synthesis and accumulation of peroxidized lipids, making cells more sensitive to ferroptosis [69,70,71]

251 Various PI3K inhibitors are currently being used in clinical trials, primarily for malignant tumours

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