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Variants in FTO, MC4R, and GIPR genes correlate with baseline weight-gain susceptibility and may inform which mechanism of action best addresses an individual's metabolic phenotype

Sci Signal 2009

AOD-9604 works through fat metabolism, not appetite suppression like GLP-1 medications

ToghaMRazeghi JahromiSGhorbaniZGhaemiARafieeP

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Diabetes itself increases NAION risk, creating particularly dangerous situations when patients take GLP-1 medications that multiply already elevated baseline risk