Treatments tailored toward the needs of individual patients based on their CKD stage and microbiome profiles via the application of different -omics approaches such as microbiome analysis, metabolomics, metagenomics, metaproteomics, nutrigenomics, and others enable the application of suitable dietary requirements, physical activity, and/or biotic supplementation that will be most beneficial to them via modulation of the microbiota, reduction of uremic toxins and inflammation, and slowing CKD progression ultimately leading to an improvement in their cognitive health and overall quality of life
Mitochondria, as the main source of cell energy as well as ROS and antioxidants, play a key role in the production of ATP, regulating apoptosis and detoxication, maintaining membrane potentials and the distributions of ions in appropriate compartments of the cell, etc
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In peptide research, this relationship is often described as a 1+1=3 effect due to the supra-additive nature of the secretagogues
Roe DR, Cheatham TE (2013) PTRAJ and CPPTRAJ: software for processing and analysis of molecular dynamics trajectory data
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