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No GP or specialist in the UK would be in a position to supervise or endorse the combined use of these two agents outside of a formal clinical trial, given the complete absence of safety and efficacy data for this combination

Nausea is the #1 reported side effect of these medications

What makes retatrutide different is its triple action approach

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In fact, there is a well-documented counter-regulatory reduction in metabolic rate in both humans (31, 32) and rodents (30, 33) treated with GLP-1R agonists for extended periods due to the reduction food intake

Hathaway JT, Shah MP, Hathaway DB, Zekavat SM, Krasniqi D, Gittinger JW Jr, et al