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Dose escalation schedules amplify these effects early in therapy and then permit physiological adaptation, which is why many patients see gradual improvement

The delay was announced this week amid concerns from insurers about costs and uncertainty over how such a program would be implemented

Biochem Biophys Res Commun 324 : 231235 Wong A, Yang J, Cavadini P, Gellera C, Lonnerdal B, Taroni F, Cortopassi G 1999 The Friedreich's ataxia mutation confers cellular sensitivity to oxidant stress which is rescued by chelators of iron and calcium and inhibitors of apoptosis

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ISSN 2213-2317