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While some lean mass loss inevitably occurs during significant weight reduction, the rate is typically 20-25% of total weight lost on tirzepatide compared to 30-40% with diet-only approaches

Various factors may have contributed to these mixed results, including participant heterogeneity, compliance issues, and the aggressive placebo response often seen in obesity trials where lifestyle modification is encouraged

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NNMT knockdown in WAT and liver protects against diet-induced obesity by augmenting cellular energy expenditure