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Its dysregulation is a hallmark of many cancers ( -catenin degradation

Collectively, NOXs and the ETC generate roughly 85% of H 2 O 2 , with the remaining production deriving from oxidases in the endoplasmic reticulum (ER) and peroxisomes, as well as from cumulative environmental stressors such as UV or ionising radiation 8,40,42,43

doi: 10.1016/j.tiv.2013.03.002 75 DonohoeDRCollinsLBWaliABiglerRSunWBultmanSJ

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GHK-Cu affects over 4,000 human genes, upregulating pathways associated with tissue maintenance and downregulating inflammatory and degenerative cascades