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While a direct mechanistic link has yet to be found, CVB infections are known to cause chronic inflammatory diseases, including myocarditis, meningitis, and pancreatitis (137)

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[7] It is important to note that glucagon receptor agonism can also increase hepatic glucose output

3.1.4.3 Strategies to bridge translational difficulties To improve clinical translatability, the following strategies are recommended: (1) Multi-species validation: mechanisms discovered in mice should be validated in rats, rabbits, or non-human primates

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Key takeaways There is no quality scientific evidence to suggest that coffee enemas provide health benefits