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Many compounds that looked effective in animals later failed human trials or revealed safety concerns

Lower baseline insulin levels reduce the ovarian drive for androgen synthesis, potentially improving acne, hirsutism, and alopecia within weeks to months of starting therapy

0.5% (n=17) in the control group, for an odds ratio of 2.15

This one strategy, acknowledged by many experienced researchers and clinicians, prevents a huge amount of unnecessary suffering and premature discontinuation

For these reasons, the use of GHSs for off-label or nonprescription purposes is not recommended

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