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Genetics and receptor sensitivity Individual variation in GLP-1 receptor expression, density, and sensitivity creates a genetic component to treatment response
These benefits may prove more valuable than the weight loss itself for long-term health outcomes
Burn off some extra energy, which can nudge the scale down
Centrally, GLP-1 receptor agonists act on hypothalamic appetite centers to increase satiety and reduce food intake
When comparing cell sources, trade-offs in potency and safety emerge
confirmed that GLP-1 was cleaved from proglucagon in the gut by cloning and sequencing the mammalian glucagon gene (Bell et al., 1983a
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