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Lysophosphatidylcholine induces oxidative stress in human endothelial cells via NOX5 activation - implications in atherosclerosis

In the early stages of diabetes, kidney hemodynamic changes, inflammation, and fibrosis occur due to metabolic alterations such as hyperglycemia, systemic hypertension, hyperaminoacidemia, and obesity

Shiao et al., 2015)

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Polyunsaturated fatty acids undergo nonenzymatic peroxidation when oxygen radicals generated by mitochondrial ROS production remove a hydrogen atom from the lipid, resulting in a lipid radical that can propagate to generate more peroxyl/alkoxyl radicals and hydroperoxide [83]