doi: 10.1111/eci.13036
In the acute phase, symptoms include euphoria, anxiety, paranoia, and psychomotor agitation, which are primarily caused by the short-term overactivation of neurotransmitter systems ( 2.3.1 Cognitive impairment METH abuse significantly impairs cognitive function by targeting key brain regions ( 2.3.2 Psychiatric symptoms METH abuse disrupts the functionality of various brain regions, including the prefrontal cortex, nucleus accumbens, and thalamus, leading to significant psychiatric disturbances ( 2.3.3 Motor dysfunction Motor dysfunction caused by METH abuse is commonly characterized by parkinsonian-like symptoms, including tremors, bradykinesia, and rigidity (Yang et al., 2018)
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