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Further cysteine-rich protein motifs that can be modified by electrophiles such as EdAG are the Zn-binding Cys 2 His 2 and Zn 2 /Cys 6 domains ( zinc finger ) of regulatory proteins such as nuclease enzymes, of DNA transcription factors and of metallothioineins [146,147]

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The counter GSSSG treatment did not increase activation activity of 1 ng/ml HGF ( left orange-bar ), consistent with the earlier observation that GSSSG did not effectively modulate the HGF-c-met interaction (Figure 1e right column, orange bars 4 and 5 ), and hence served as a control trisulfide