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When treating migraines, two factors should be taken into account: first, pre-treatment education for patients, which includes avoiding migraine triggers and improving lifestyle choices

Before-and-after documentation is also helpful if you ever need to demonstrate progress to your prescribing physician for protocol adjustments

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The subsequent downstream signaling cascade initiated from substrates of the insulin receptor activates kinases and transcription factors vital in promoting cell metabolism, neuronal growth and differentiation, gene transcription, synaptic plasticity, and neuroprotection [133] (Fig