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Insurers also introduced novel metabolic health programs: for instance, in 2026 CVS Caremark announced a Weight Management UM Bundle to automatically apply evidence-based PA criteria on new GLP-1 agents, reducing ad-hoc appeals ( [34] ) ( [35] )
Pharmacological substances not approved for human therapeutic use by any governmental regulatory authority are included in this category
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They are not independently tested for bioequivalence, meaning there is no guarantee that the compounded product delivers the same amount of active ingredient as the FDA-approved version
Nature Hong et al
Obesity 30 , 802840 (2022)
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