For weight loss treatments, the patient may come in with an expressed desire to start semaglutide treatment to lose weight, and that may initially appear like a viable option
It also notes GLP-1 users show modest reductions in total body water during weight-loss phases
Long-term efficacy trajectories of GLP-1 receptor agonists: a systematic review and network meta-analysis, Diabetes, Metabolic Syndrome and Obesity (2025) The effect of early response to GLP-1 RA therapy on long-term adherence and persistence among Type 2 diabetes patients in the United States, Journal of Managed Care & Specialty Pharmacy (2019) Weight loss between glucagon-like peptide-1 receptor agonists and bariatric surgery in adults with obesity: A systematic review and meta-analysis, Obesity (2022) FDA approves first medication for obstructive sleep apnea, U.S
Retatrutide (compounded, investigational) As a triple agonist (GLP-1, GIP, glucagon), retatrutide is the most complex molecule of the three
You may eat significantly less than before, which can be great for your weight loss goals but may leave your body with fewer calories to burn for energy
It also calls for quarterly check-ins during the first year and informed consent around bone density and lipid shifts