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Start with a lower dose and gradually increase the dose until the optimal dose is reached

Although the mechanism that leads to the depletion of Th17 cells remains largely unknown, some of the proposed mechanisms include (i) a lack of HIV-inhibitory RNases in human Th17 cells leading to early, sustained depletion [59], (ii) decreased levels of IL-21-producing cells responsible for maintaining Th17 cells [60], and (iii) a depletion of CD103+ dendritic cells which promote Th17 differentiation [61]

someone can have seizures, high blood pressure, a rapid heartbeat, and even a heart attack

People who drop at least 5% of their body weight by week 16 tend to keep losing

In SURMOUNT-1, around 4 to 7% of people on tirzepatide stopped the medication because of side effects, compared with 2.6% on placebo

Gastrointestinal effects are particularly relevant