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Clinical Data, Treatment Intensification, and Long-Term Parameter Progression Baseline cohort characteristics were based on the total population of the PIONEER 4 clinical trial, with means and standard deviations informing sampling of characteristics in the PRIME T2D Model, leading to the generation of 500,000 unique patients that were modeled in both treatment arms of the analysis (Table 1) [11]

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SdaA was reported to be the gene encoding either the structural gene of L-SD that catalyzes the deamination of serine to pyruvate or a positive activator of transcription [31]

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