The positive control used was topiroxostat, which showed an IC 50 of 17 nM, very close to compound 72 , the most active compound in the study (Figure 23)
Pillon, Gunnar Schulte, Roger J
Why Its GLP-1 Friendly & Health-Conscious
Thyroid eye disease can be explained simply by saying that it is a disease where autoantibodies target specific eye cells, causing them to bulge out and compress the optic nerve
Additionally, accumulation of the -synuclein activates stimulation of the microglia with subsequent expression of NLRP3 inflammasome in the SN (Cant and Auwerx 2009
If your genetics suggest reduced GIPR function but strong MC4R regulation, a combination approach like GLP-Squared (semaglutide plus tirzepatide) could unlock better outcomes